General Information

  • ID:  hor000302
  • Uniprot ID:  NA
  • Protein name:  Allatostatin A
  • Gene name:  NA
  • Organism:  Ascaris suum
  • Family:  Allatostatin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  DRLYSFGL
  • Length:  8
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  T8 Leucine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Exhibited significant inhibitory effects on ovijector at 10 microM
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor000302_AF2.pdbhor000302_ESM.pdb

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Physical Information

Mass: 109513 Formula: C45H67N11O13
Absent amino acids: ACEHIKMNPQTVW Common amino acids: L
pI: 6.34 Basic residues: 1
Polar residues: 3 Hydrophobic residues: 3
Hydrophobicity: -1.25 Boman Index: -1342
Half-Life: 1.1 hour Half-Life Yeast: 3 min
Half-Life E.Coli: >10 hour Aliphatic Index 97.5
Instability Index: -67.5 Extinction Coefficient cystines: 1490
Absorbance 280nm: 212.86

Literature

  • PubMed ID:  16185693
  • Title:  Expression and Bioactivity of Allatostatin-Like Neuropeptides in Helminths